Breakthrough Saliva Discovery:

Evidence proves saliva a more consistent & sensitive biosample when testing for COVID-19

Saliva is one of our biggest foes in the COVID-19 pandemic, because of its role in spreading the virus. But it could also prove to be our very best friend too offering a way to diagnose the disease without using invasive nasal swabs.

When COVID-19 testing began in earnest, the most common biosample used to test for the virus was the nasopharyngeal approach, which required a medical professional to conduct a (usually painful) nasal swab on a patient. This, coupled with risk to healthcare workers and a global shortage of swabs for sampling caused researchers around the world to seek viable alternatives.

NEW EUA MESSAGE SDNA-1000

Rutgers Study Proves Viability of Saliva Samples for COVID-19 Tests

Dr. Andrew Brooks, COO at RUCDR

[Dr. Andrew Brooks, COO at RUCDR]

A clinical study by Rutgers’ RUCDR Infinite Biologics evaluated the use of saliva as a specimen type for detection of SARS-CoV-2 in patients who are suspected of COVID-19. The study exclusively used the Spectrum Solutions LLC SDNA-1000 Saliva Collection Device. Results successfully validated saliva as being a viable biosample source for COVID-19 detection when compared to nasopharyngeal or oropharyngeal swabs. The resourceful discovery came just in time to deliver a better testing solution as traditional testing supplies became increasingly difficult to find including swabs and personal protective equipment. FDA issued EUA based on these findings.

  • Breakthrough Results: There was 100% positive and negative agreement between the results obtained from testing of saliva and those obtained from nasopharyngeal and oropharyngeal swabs. Researchers at Rutgers’s RUCDR Infinite Biologics compared swab-collected biosamples head-to-head against saliva biosamples using the Spectrum DNA whole saliva collection device and its patented blue preservation solution. Saliva not only demonstrated to be a robust source of viral RNA but when preserved with Spectrum’s patented preservation solution it was seen to deliver 100% inactivation of the live virus. Additionally, Spectrum’s saliva collection device provided over 10-days of post-collection stability with no degradation of sample efficacy. Self-collection along with the inactivation of the virus creates the most robust and safest biomaterial collection approach for the detection of COVID-19 infections.
  • Researcher Quote: “The impact of this authorization is significant,” said Andrew Brooks, chief operating officer and director of technology development at RUCDR, who also is a professor in the School of Arts and Sciences Department of Genetics at Rutgers University–New Brunswick. “It means we no longer have to put health care professionals at risk for infection by performing nasopharyngeal or oropharyngeal collections. We can preserve precious personal protective equipment for use in patient care instead of testing. We can significantly increase the number of people tested each and every day as the self-collection of saliva is more quick and scalable than swab collections. All of this combined will have a tremendous impact on testing … across the United States.”
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University of Queensland:

Is Saliva Friend?Foe?

Diagnostics-saliva COVID-19The coronavirus disease 2019 (COVID-19) outbreak, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global ongoing pandemic. Timely, accurate, and non-invasive SARS-CoV-2 detection in both symptomatic and asymptomatic patients, as well as the determination of their immune status, will facilitate effective large-scale pandemic control measures to prevent the spread of COVID-19. This review focuses on the role of saliva as both a foe (a common mode of viral transmission via salivary droplets and potentially aerosols) and a friend (as a non-invasive diagnostic tool for viral detection and immune status surveillance) in combating COVID-19.

This review explores the potential role of saliva in the COVID-19 pandemic, as both a mechanism for the spread of the disease and a readily accessible diagnostic tool for detecting the presence of the virus, as well as an individual’s immune status.

  • Results: saliva can be used to diagnose the novel coronavirus infection, and even help monitor immunity to the virus.
  • Saliva is a “potent” biofluid source option for the detection of SARS-CoV-2 since it is non-invasive, easy-to-access, and low-cost.
  • Saliva can be stored at -80 °C for several years with little degradation.
  • Researcher Quote: “Ironically, saliva is a leading way that disease is transmitted, via droplets on surfaces and in the air, but it can also be incredibly useful to us for diagnosing the virus and monitoring a person’s health,” said Dr. Pingping Han, a postdoctoral research fellow in UQ’s School of Dentistry. “Indeed, saliva may be useful for both diagnosing the presence and sequelae of COVID-19 infection, as well as identifying and tracking the development of immunity to the virus.”

 

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Received: 21 April 2020 / Revised: 6 May 2020 / Accepted: 7 May 2020 / Published: 9 May 2020
Han, P.; Ivanovski, S. Saliva—Friend and Foe in the COVID-19 Outbreak. Diagnostics 2020, 10, 290.

Yale University:

Saliva offers GREATER detection sensitivity and consistency than nasal swabs.

Yale University Research Study Proof Point- Saliva More Sensitive for COVID-19 Detection Than Naso-Swabs50 researchers at Yale University sought to validate saliva as a new diagnostic approach over nasopharyngeal swabs because swabs offer low sensitivity, exposure risks to healthcare workers, and global shortages of swabs and personal protective equipment.

  • Results: Saliva samples taken from just inside the mouth provided greater detection sensitivity and consistency throughout the course of an infection than the broadly recommended nasopharyngeal (NP) approach.
  • The study also concluded: there was less variability in results with the self-sample collection of saliva.
  • Researcher Quote: “Taken together, our findings demonstrate that saliva is a viable and more sensitive alternative to nasopharyngeal swabs and could enable at-home self-administered sample collection for accurate large-scale SARS-CoV-2 testing,” said first author Anne Wyllie, an associate research scientist at the Yale School of Public Health and a member of its Public Health Modeling Unit.
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About the Product

Innovative Engineering

Spectrum-SDNA-1000-Saliva-Collection-Proud Partner of MLB2

Spectrum Solutions has manufactured over 20 million Saliva Collection devices for distribution worldwide. Spectrum’s technically superior  SDNA-1000 saliva collection device was engineered to lead the saliva collection industry in molecular diagnostics and clinical research applications delivering the safest and most robust biomaterial collection approach for the detection and diagnosis of disease or viral infection.

  • First saliva collection device to receive EUA authorization for COVID-19 testing
  • First saliva collection device FDA authorized for at-home sample collection
  • Only pain-free biosample collection option for COVID-19 testing
  • Engineered to reduce self-collection error
  • Delivers consistent high-quality, high-yield biosamples
  • 100% inactivation of the live virus
  • 100% bacteriostatic
  • Delivers over a 90% reduction in PPE usage compared to current swab collections for COVID-19 testing
  • Single device preserves both DNA and fragile viral RNA transcripts
  • Device stabilizes and extends biosample viability post-collection over 10 days with no degradation of sample efficacy extending shipping and transport options
  • Saliva collection system mitigates any risk of infection throughout the testing process
  • Pinpoint life-cycle stage of active viral infection
Questions? Let’s Connect
Spectrum-SDNA-1000-Saliva-Collection-Proud Partner of MLB2

About the Product

Innovative Engineering

Spectrum Solutions has manufactured over 20 million Saliva Collection devices for distribution worldwide. Spectrum’s technically superior  SDNA-1000 saliva collection device was engineered to lead the saliva collection industry in molecular diagnostics and clinical research applications delivering the safest and most robust biomaterial collection approach for the detection and diagnosis of disease or viral infection.

  • First saliva collection device to receive EUA authorization for COVID-19 testing
  • First saliva collection device FDA authorized for at-home sample collection
  • Only pain-free biosample collection option for COVID-19 testing
  • Engineered to reduce self-collection error
  • Delivers consistent high-quality, high-yield biosamples
  • 100% inactivation of the live virus
  • 100% bacteriostatic
  • Delivers over a 90% reduction in PPE usage compared to current swab collections for COVID-19 testing
  • Single device preserves both DNA and fragile viral RNA transcripts
  • Device stabilizes and extends biosample viability post-collection over 10 days with no degradation of sample efficacy extending shipping and transport options
  • Saliva collection system mitigates any risk of infection throughout the testing process
  • Pinpoint life-cycle stage of active viral infection
Questions? Let’s Connect