Dr. David Wong of UCLA to Present Saliva Liquid Biopsy Research Findings with Collection Advantages at ASHG 2022

PRESS RELEASE
Leslie Titus Bryant
October 25, 2022

ASHG 2022 Annual MeetingSALT LAKE CITY, UTAH—Spectrum Solutions, LLC today announced David T.W. Wong, D.M.D., D.M.SC. of the UCLA School of Dentistry will present at the American Society of Human Genetics (ASHG) Annual Meeting 2022 on Friday, Oct. 28 at 1:00 p.m. in the CoLab Theater. This presentation will highlight the new era of saliva as a non-invasive biospecimen for CLIA-validated liquid biopsies in non-small cell lung cancer. Working from bench to bedside, the clinical utility of salivary liquid biopsies provides opportunities for both ongoing surveillance and continued monitoring following treatment.

Previous research by UCLA researchers demonstrated the detection of actionable EGFR mutations in non-small cell lung cancer (NSCLC) patients using saliva delivering a 96% and 100% sensitivity/concordance with serum. Published in The BIO Journal, Dr. Wong’s research demonstrates the ability to detect circulating tumor DNA (ctDNA) within saliva using the Electric Field–Induced Release and Measurement (EFRIM) electrostatic platform and goes a step further highlighting the superior ability and benefits of stabilized and preserved saliva using Spectrum’s SDNA-1000 saliva collection kit compared to raw saliva. Study findings illustrate and credit Spectrum’s patented stability and preservation technology for dramatically increasing sensitivity and delivering a significant 14-fold boost in signal detection for all three EGFR mutations (p<0.0001) associated with NSCLC. Additional benefits of Spectrum’s saliva collection system included improving assay reproducibility and decreasing sample variability among study participants.

Dr. Wong is a Distinguished Professor in the Division of Oral and Systemic Health Sciences, Director of the UCLA Center for Oral/Head and Neck Research, and an active scientist in oral cancer and saliva diagnostics research. He has authored over 315 peer-reviewed scientific publications and is a fellow of the American Association for the Advancement of Sciences (AAAS), a past member of the ADA Council of Scientific Affairs, past president of the American Association of Dental Research (AADR), chair of the NCI Liquid Biopsy Consortium, chair of the NIH Cancer Biomarker Study Section, and a member of the scientific advisory board for Spectrum Solutions.

In addition, Spectrum will be introducing its new saliva-based multi-omic collection platform with the first preservation buffer purpose-built to stabilize and preserve both salivary proteins and genomic material post-collection for multiple days at room temperature. For more information on this or Dr. Wong’s presentation stop by booth number 2123.

Click here to view this press release on the Business Wire.

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Dr. David Wong of UCLA to Present Saliva Liquid Biopsy Research Findings with Collection Advantages at ASHG 2022

PRESS RELEASE
Leslie Titus Bryant
October 25, 2022

SALT LAKE CITY, UTAH—Spectrum Solutions, LLC today announced David T.W. Wong, D.M.D., D.M.SC. of the UCLA School of Dentistry will present at the American Society of Human Genetics (ASHG) Annual Meeting 2022 on Friday, Oct. 28 at 1:00 p.m. in the CoLab Theater. This presentation will highlight the new era of saliva as a non-invasive biospecimen for CLIA-validated liquid biopsies in non-small cell lung cancer. Working from bench to bedside, the clinical utility of salivary liquid biopsies provides opportunities for both ongoing surveillance and continued monitoring following treatment.

Previous research by UCLA researchers demonstrated the detection of actionable EGFR mutations in non-small cell lung cancer (NSCLC) patients using saliva delivering a 96% and 100% sensitivity/concordance with serum. Published in The BIO Journal, Dr. Wong’s research demonstrates the ability to detect circulating tumor DNA (ctDNA) within saliva using the Electric Field–Induced Release and Measurement (EFRIM) electrostatic platform and goes a step further highlighting the superior ability and benefits of stabilized and preserved saliva using Spectrum’s SDNA-1000 saliva collection kit compared to raw saliva. Study findings illustrate and credit Spectrum’s patented stability and preservation technology for dramatically increasing sensitivity and delivering a significant 14-fold boost in signal detection for all three EGFR mutations (p<0.0001) associated with NSCLC. Additional benefits of Spectrum’s saliva collection system included improving assay reproducibility and decreasing sample variability among study participants.

Dr. Wong is a Distinguished Professor in the Division of Oral and Systemic Health Sciences, Director of the UCLA Center for Oral/Head and Neck Research, and an active scientist in oral cancer and saliva diagnostics research. He has authored over 315 peer-reviewed scientific publications and is a fellow of the American Association for the Advancement of Sciences (AAAS), a past member of the ADA Council of Scientific Affairs, past president of the American Association of Dental Research (AADR), chair of the NCI Liquid Biopsy Consortium, chair of the NIH Cancer Biomarker Study Section, and a member of the scientific advisory board for Spectrum Solutions.

In addition, Spectrum will be introducing its new saliva-based multi-omic collection platform with the first preservation buffer purpose-built to stabilize and preserve both salivary proteins and genomic material post-collection for multiple days at room temperature. For more information on this or Dr. Wong’s

Click here to view this release on the Business Wire.

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Noninvasive
Saliva Diagnostics

This changes everything

Health is a dynamic state of well-being. Healthcare providers and researchers have long believed that changes in our saliva record our ongoing state-of-health story. Interestingly, saliva acts as a wide resource of genomic information useful for identifying and monitoring in real-time a disease as well as its state of progression. Saliva analysis looks at the cellular level, the biologically active compounds, making it a true representative of what is clinically relevant.

Spectrum’s technically-superior saliva collection systems have not only been engineered to lead the saliva collection industry in molecular diagnostics and clinical research applications but deliver the safest, most robust biomaterial for the earliest detection and diagnosis of disease and infection.

  • Saliva provides the earliest path to critical detection and diagnosis
  • Saliva contains the entire library of proteins, hormones, antibodies, and other molecular compounds measured in routine blood tests
  • First EUA authorized saliva collection device for COVID-19 testing & authorized device for direct-to-patient at-home sample self-collection
  • Used in supervised & unsupervised sample collection LDT workflows of symptomatic & asymptomatic users
  • Pain-free, non-invasive, & safe – ideal for those needing frequent & repeat testing
  • In-device live virus inactivation at ambient temps (COVID-19 EUA validated data)
  • Eliminates hooded containment of samples arriving at the testing lab
  • No temperature-controlled storage or transport of collected saliva samples
  • Single device for DNA & viral RNA applications
  • Safest collection approach & most robust biomaterial for detecting COVID-19
  • Delivers 99.998% highest levels of testing accuracy & sensitivity
  • Formulation identifies infections at its earliest stage from as few as 200 copies/ml (lateral flow rapid tests need 10,000-20,000 copies/ml)
  • A single preserved saliva sample provides opportunity for multiple tests
  • Over two weeks of post-collection stability with no degradation in sample efficacy
  • System maintains critical bio-sample consistency
  • Mass-testing scalability & easy device integration using validated and supported processes
  • Mitigates any risk of infection throughout the testing process
  • Pinpoint life-cycle stage of active viral infection
  • Eliminates UN3373 shipping designation with clearance from USPS, FedEx, & UPS
  • Delivers the highest levels of testing accuracy using qualified extraction chemistries
Questions, Let’s Connect!

Noninvasive
Saliva Diagnostics

This changes everything

Health is a dynamic state of well-being. Healthcare providers and researchers have long believed that changes in our saliva record our ongoing state-of-health story. Interestingly, saliva acts as a wide resource of genomic information useful for identifying and monitoring in real-time a disease as well as its state of progression. Saliva analysis looks at the cellular level, the biologically active compounds, making it a true representative of what is clinically relevant.

Spectrum’s technically-superior saliva collection systems have not only been engineered to lead the saliva collection industry in molecular diagnostics and clinical research applications but deliver the safest, most robust biomaterial for the earliest detection and diagnosis of disease and infection.

  • Saliva provides the earliest path to critical detection and diagnosis
  • Saliva contains the entire library of proteins, hormones, antibodies, and other molecular compounds measured in routine blood tests
  • First EUA authorized saliva collection device for COVID-19 testing & authorized device for direct-to-patient at-home sample self-collection
  • Used in supervised & unsupervised sample collection LDT workflows of symptomatic & asymptomatic users
  • Pain-free, non-invasive, & safe – ideal for those needing frequent & repeat testing
  • In-device live virus inactivation at ambient temps (COVID-19 EUA validated data)
  • Eliminates hooded containment of samples arriving at the testing lab
  • No temperature-controlled storage or transport of collected saliva samples
  • Single device for DNA & viral RNA applications
  • Safest collection approach & most robust biomaterial for detecting COVID-19
  • Delivers 99.998% highest levels of testing accuracy & sensitivity
  • Formulation identifies infections at its earliest stage from as few as 200 copies/ml (lateral flow rapid tests need 10,000-20,000 copies/ml)
  • A single preserved saliva sample provides opportunity for multiple tests
  • Over two weeks of post-collection stability with no degradation in sample efficacy
  • System maintains critical bio-sample consistency
  • Mass-testing scalability & easy device integration using validated and supported processes
  • Mitigates any risk of infection throughout the testing process
  • Pinpoint life-cycle stage of active viral infection
  • Eliminates UN3373 shipping designation with clearance from USPS, FedEx, & UPS
  • Delivers the highest levels of testing accuracy using qualified extraction chemistries
Questions, Let’s Connect!
Major League Baseball Logo

Bringing Baseball Back!

How you collect saliva makes a big
diagnostic difference

Increase workplace safety and build team confidence with simple and safe repeat testing programs supporting 100% accurate early detection and easy direct-to-user at-home options. Just ask the MLB, real-world, mass testing scenarios require an authorized, proven, and supported system that mitigates any risk of exposure. See how our saliva collection system is credited for bringing baseball back” and making Salt Lake “the league’s most important city”.

™/© 2020 MLB

Case Study
Major League Baseball Logo

Bringing Baseball Back!

How you collect saliva makes a big
diagnostic difference

Increase workplace safety and build team confidence with simple and safe repeat testing programs supporting 100% accurate early detection and easy direct-to-user at-home options. Just ask the MLB, real-world, mass testing scenarios require an authorized, proven, and supported system that mitigates any risk of exposure. See how our saliva collection system is credited for bringing baseball back” and making Salt Lake “the league’s most important city”.

™/© 2020 MLB

Case Study

Why Spectrum?

Headquartered in Salt Lake City, Utah, Spectrum Solutions® is a clinical science innovation leader and a specialized laboratory test ideation and commercialization partner. Our patented, noninvasive, and multi-omic specimen collection and preservation capabilities are setting new standards of modernized care for patients, providers, and laboratories in the testing, managing, and treatment of disease.

We believe when you bridge the gap between science and real direct-to-patient medical solutions you deliver innovation with the practical power to impact and change outcomes. Learn more Spectrum Medical Science SM, Spectrum Compounding Pharmacy TM, and Spectrum Clinical Manufacturing SM.

#partoftheSolution

Leslie Titus Bryant Spectrum Solutions SpokesmanSpectrum Corporate Spokesman
Leslie Titus Bryant
Head of Marketing & Brand
admin@spectrumsolution.com

Tim Rush Public Relations, Springboard 5Media Contact
Tim Rush, Springboard5
801-208-1100
tim.rush@springboard5.com

Why Spectrum?

Headquartered in Salt Lake City, Utah, Spectrum Solutions® is a clinical science innovation leader and a specialized laboratory test ideation and commercialization partner. Our patented, noninvasive, and multi-omic specimen collection and preservation capabilities are setting new standards of modernized care for patients, providers, and laboratories in the testing, managing, and treatment of disease.

We believe when you bridge the gap between science and real direct-to-patient medical solutions you deliver innovation with the practical power to impact and change outcomes. Learn more Spectrum Medical Science SM, Spectrum Compounding Pharmacy TM, and Spectrum Clinical Manufacturing SM.

#partoftheSolution

Leslie Titus Bryant Spectrum Solutions SpokesmanSpectrum Corporate Spokesman
Leslie Titus Bryant
Head of Marketing & Brand
admin@spectrumsolution.com

Tim Rush Public Relations, Springboard 5Media Contact
Tim Rush, Springboard5
801-208-1100
tim.rush@springboard5.com

Can we answer any questions?

Let's Connect

Contact Us

#SpitMatters

Can we answer any questions?

Let's Connect

Contact Us

#SpitMatters

Outside-of-the-Box Thinking, Inside-of-the-Box Clinical Innovation

Anywhere from customized testing solutions to new medical science product innovations–we’re here to help.

Outside-of-the-Box Thinking, Inside-of-the-Box Innovation

Anywhere from customized testing solutions to new medical science product innovations–we’re here to help.

2022-10-25T19:55:19+00:00
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