Oral health isn’t separate from systemic health. It never was.

In functional medicine, the mouth isn’t separate from the body, it’s a mirror of what’s happening systemically.

The SimplyTest Oral-Systemic panel is a comprehensive, saliva-based test that features complete multi-organism detection capability for all keystone periodontal and systemic oral health pathogens, offering deeper insight into both oral and whole-body health.

Periodontal disease (gum disease) is a polymicrobial biofilm infection that results in the breakdown of tissue and bone, which, when left untreated, can lead to tooth loss. The bacteria can travel through bone and gum tissue into the bloodstream, affecting overall health.

Inflammation and microbial imbalance can exacerbate or initiate systemic dysfunction, especially in already compromised individuals. From cardiovascular risk and autoimmune reactivity to metabolic disorders, oral pathogens are proven contributors to whole-body imbalance.

This is more than an oral health test. It’s a clinical tool for deeper insight into chronic disease drivers, microbial burden, and inflammation that often begins in the mouth, but doesnt’ stay there.

Periodontal disease (gum disease) is often silent in its early stages, yet its microbial contributors can trigger systemic effects long before symptoms appear.

Oral pathogens have been linked to:
• Cardiovascular disease
• Type 2 diabetes & insulin resistance
• Autoimmune conditions including rheumatoid arthritis
• GI inflammation and gut dysbiosis
• Cognitive decline and Alzheimer’s disease
• Adverse pregnancy outcomes

Whether you’re directly treating or guiding your patient’s care, SimplyTest provides insight into the oral microbial imbalances contributing to systemic dysfunction helping you deliver more effective, personalized care.

Join a growing community of providers who believe prevention is powerful, precision is possible, and oral health is systemic health.

  • Complete multi-organism detection for keystone periodontal & oral-systemic pathogens in a single test
  • Noninvasive saliva sample collection
  • In-device sample storage & transport at room temperature
  • Actionable insights to support treatment & track progress over time
  • View Sample Report

Oral-Systemic Testing Targets

Purple Complex
Aggregatibacter actinomycetemcomitans (Aa)
Red Complex
Porphyromonas gingivalis (Pg)
Treponema denticola (Td)
Tannerella forsythia (Tf)
Orange Complex
Prevotella intermedia (Pi)
Campylobacter rectus (Cr)
Fusobacterium nucleatum (Fn)
Fusobacterium animalis (Fa)
Green Complex
Eikenella corrodens (Ec)
Caries
Streptococcus mutans (Sm)
Streptococcus sanguinis* (Ss)
Yeast
Candida albicans (Ca)
Peri-Implantitis Risk
Pseudomonas aeruginosa (Pa)
Viral Targets
Herpes Simplex Virus 1 (HSV-1)
Herpes Simplex Virus 2 (HSV-2)
Cytomegalovirus
Epstein Barr Virus
*The presence of Streptococcus sanguinis is associated with healthy plaque biofilm.

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